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Cancers in 2012 due to overweight and obesity: the Czech Republic has the highest proportion in Europe

A new study by the International Agency for Research on Cancer (IARC), the specialised cancer agency of the World Health Organization (WHO), shows that nearly half a million new cancer cases per year can be attributed to high body mass index (BMI).

The study, published in The Lancet Oncology [1], highlights that being overweight or obese has become a major risk factor, responsible for an estimated 3.6% (481 000) of all new cancer cases in 2012. Proportions of new cancer cases attributable to high BMI in individual countries were expressed as population attributable fractions (PAFs).

Striking global disparities

Global analysis shows that cancer due to being overweight or obese is currently far more common in more developed countries (393 000 cases, 5.2% of all new cancer cases in these countries) than in less developed countries (88 000 cases, 1.5% of all new cancer cases in these countries). Figs. 1 and 2 show the global burden of cancer attributable to high BMI in 2012 on the world map (darkest shades representing populations most burdened with cancer attributable to high BMI).

Fig. 1: Estimated population attributable fractions (PAFs) of new cancer cases in 2012 caused by high BMI in men, by country.
Source: Lancet Oncol [1]
Fig. 2: Estimated population attributable fractions (PAFs) of new cancer cases in 2012 caused by high BMI in women, by country.
Source: Lancet Oncol [1]

North America remains the most affected, with an estimated 111,000 obesity-related cancers in 2012, accounting for 23% of the total global cancer burden linked to high BMI.

Fig. 3: Estimated population attributable fractions (PAFs), % out of total cancers associated with high BMI by country in 2012, Europe: men (left) and women (right).

In Europe, the proportion of cancers due to high BMI is also large, particularly in eastern Europe (65 000 cases, 6.5% of all new cancer cases in the region). Sadly, the Czech Republic has the highest proportion of cancers related to overweight or obesity, both in men (5.5%) and in women (12.0%). Fig. 3 shows the comparison of this parameter among individual European countries. According to the most recent data by Eurostat [2], 65.5% of men and 48.1% of women in the Czech Republic are overweight or obese, which is the 4th and the 6th highest proportion among 19 evaluated EU countries, respectively.

Although in most Asian countries the proportion of cancers associated with overweight and obesity is not large, it still translates into a considerable absolute number of cases, due to the large population size. For example, in China, about 50,000 cancer cases in women and men are associated with excess weight and obesity, accounting for 1.6% of the country’s new cancer cases.

In contrast, the contribution of excess weight and obesity to cancer burden remains low in Africa (7300 cases, 1.5% of all new cancer cases in the continent).

Women are more affected

High BMI is a known risk factor for cancers of the oesophagus, colon, rectum, kidney, pancreas, gallbladder, postmenopausal breast, ovary, and endometrium, as well as for other noncommunicable diseases, notably cardiovascular disease and diabetes.

The study highlights that the proportion of cancers related to obesity is higher in women than in men, with population attributable fractions of 5.3% and 1.9%, respectively. “Women are disproportionately affected by obesity-related cancers,” says IARC’s Dr Melina Arnold, one of the study’s lead authors, “For example, for postmenopausal breast cancer, the most common cancer in women worldwide, the study suggests that 10% of these cancers could have been prevented by having a healthy body weight.” Cancers of the endometrium, colon, and breast account for almost three quarters (73%) of all cancers linked to high BMI in women.

In men, kidney and colon cancers together account for two thirds (66%) of all cancers associated with high BMI.

Potential for prevention

“These worrying results highlight that it’s crucial to maintain a healthy weight to prevent so many common cancers,” says Dr Kate Allen, Executive Director of Science and Public Affairs at World Cancer Research Fund International, which funded the project.

“In the United Kingdom, 13,000 cases diagnosed in 2012 in women (8.2% of all cancers) could be ascribed to overweight and obesity. It’s also alarming to see that men in the UK are fourth in the world in this obesity cancer league table, with 6,000 cases (4.4% of all cancers) attributed to being overweight or obese. Cancer is an epidemic problem, and to tackle it we need to help people take measures to be a healthy weight.”

Reducing excess weight and obesity at the population level could have significant health benefits, including reducing the burden of cancer.

The study also shows that one quarter of all cancers attributable to excess weight and obesity worldwide (118,000 cases) could have been prevented if populations had simply maintained their average BMI of 30 years ago.

“The number of cancers linked to obesity and overweight is expected to rise globally along with economic development,” says Dr Christopher Wild, Director of IARC.

“This study stresses the importance of putting in place efficient weight control measures, to curb the high number of cancers associated with excess body weight and to avoid the problems faced by rich countries being repeated in those now undergoing rapid development.”


  1. Arnold, M., Pandeya, N., et al. (2014). Global burden of cancer attributable to high body-mass index in 2012: a population-based study The Lancet Oncology DOI: 10.1016/S1470-2045(14)71123-4
  2. Eurostat: Overweight and obesity - BMI Statistics


Keywords: cancer, overweight, obesity, body mass index (BMI), World Health Organization (WHO), International Agency for Research on Cancer (IARC)

26. 11. 2014 International Agency for Research on Cancer (IARC), Institute of Biostatistics and Analyses (IBA MU)