Mutation patterns identified in a range of human tumours
Comprehensive analyses of mutation patterns in human tumours is essential for a full understanding of the biochemical processes underlying the disease, but the scale of these has so far been limited by the sequencing technology available to either a small number of samples or a small number of genes.
Now, however, a large group of researchers from Genentech, Affymetrix and Pennsylvania State University has used the novel technology of mismatch repair detection (MRD)* to analyse regions of DNA that include over 1,500 putative protein-coding genes in samples from 441 tumours. The tumours studied were mainly breast, ovarian, lung and prostate cancers with different genetic profiles; the genes included many known to be linked with cancer or otherwise believed to be useful drug targets.
Read the whole article at ecancermedicalscience
Reference
- Kan, Z., Jaiswal, B.S., Stinson, J. and 29 others (2010). Diverse somatic mutation patterns and pathway alterations in human cancers. Nature 466, 869-873. DOI: 10.1038/nature09208
Notes
*A full description of this technique is available in the online-only version of Nature (12 August 2010).
Keywords: mismatch repair detection, mutation, genes
22. 10. 2010 ecancermedicalscience
